Anti-arrhythmic effect

Ramipril reduced the severity of ischaemia-induced arrhythmias and improved coronary flow in rats and guinea pigs.

Vasoprotection
• Vasodilation
• Inhibition of smooth muscle cell proliferation

Ramipril inhibits both the protection of systemic and local angiotensin II, and the degradation of systemic and endothelium-delivered bradykinin. Ramipril produces several beneficial effects within blood vessel walls, including vasodilation and inhibition of smooth muscle cell proliferation. Ramipril has been shown to be vasoprotective in rats, rabbits, humans and dogs. These effects are via enhanced NO availability, and are even produced by doses that do not affect systemic blood pressure.